Effects of short-term hypoxia on platelet counts of mice

摘要: Recent studies have shown that long-term hypoxia causes decreased platelet counts in mice and short-term increased counts. In an attempt to explain the mechanism increases of after exposure hypoxia, we measured counts, total circulating (TCPC), masses (TCPM), percentages 35S incorporation, sizes. Platelet as well TCPC TCPM mice, 1-3 days but these values were 6-7 hypoxia. Although hypoxic percentage incorporation into platelets sizes did not show a concurrent increase. After 6 average diameters began increase decreased. Splenic release account for It seems possible, therefore, megakaryocytes "shed" circulation response The enter are smaller incorporate less than produced acute thrombocytopenia.