CAPACITIVE COUPLING ELECTRIC FIELDS IN THE TREATMENT OF VERTEBRAL COMPRESSION FRACTURES.

摘要: Positive effects of Capacitive Coupling Electric Field (CCEF) stimulation are described for several orthopedic indications such as the healing recent fractures, non-unions and spinal fusion, due to capacity involve up-regulation osteopromotive factors. In vitro studies on MC3T3-E1 bone cells showed that CCEF acts opening plasma membrane voltage gated calcium channels, thus increasing cytosolic concentration phospholipase A2 (PLA2) activity. Cytosolic activates calmodulin pathway, resulting in an up-regulated expression osteogenic genes, transforming growth factor-β superfamily genes (TGF-β1, -β2 -β3, morphogenetic protein-2 -4), fibroblast factor (FGF)-2, osteocalcin (BGP) alkaline phosphatase (ALP). PLA2 synthesis Prostaglandin E2 (PGE2), which promotes osteogenesis by raising cellular L-ascorbic acid uptake through carrier sodium vitamin C transporter-2 (SVCT-2). vivo, Brighton et al. a castration-induced osteoporosis animal model, demonstrated was able restore mass/unit volume rat vertebral body. To investigate role marrow edema (VBME) its percentage assessed 24 patients with 25 acute compression fractures (VCFs) conservatively treated (group A) or without B) using serial MR imaging follow-up at 0, 30, 60, 90 days. Pain quality life were visual analog scale (VAS) Oswestry Low Back Disability Index (ODI) same periods. At day complete resolution VBME found only group A (p=0.0001). significant improvement VAS (p=0.007) ODI (p=0.002) also observed A. This preliminary observational study shows present clinical symptoms faster fracture resolution.