Genome-Wide Association Studies of Drug-Resistance Determinants.
作者： Sarah K. Volkman , Jonathan Herman , Amanda K. Lukens , Daniel L. Hartl
关键词:
摘要: Population genetic strategies that leverage association, selection, and linkage have identified drug-resistant loci. However, challenges limitations persist in identifying drug-resistance loci malaria. In this review we discuss the basis of drug resistance use genome-wide association studies, complemented by selection to identify understand mechanisms response. We also implications nongenetic recently reported literature, present models interplay between processes contribute emergence resistance. Throughout, examine artemisinin as an example emphasize phenotypes suitable for population studies well complications due multiple-factor
sci-hub.se 参考文章(136)
Uchechi E. Ukaegbu, Kirk W. Deitsch, The Emerging Role for RNA Polymerase II in Regulating Virulence Gene Expression in Malaria Parasites PLOS Pathogens. ,vol. 11, pp. e1004926- ,(2015) , 10.1371/JOURNAL.PPAT.1004926
Rachel F. Daniels, Stephen F. Schaffner, Edward A. Wenger, Joshua L. Proctor, Hsiao-Han Chang, Wesley Wong, Nicholas Baro, Daouda Ndiaye, Fatou Ba Fall, Medoune Ndiop, Mady Ba, Danny A. Milner, Terrie E. Taylor, Daniel E. Neafsey, Sarah K. Volkman, Philip A. Eckhoff, Daniel L. Hartl, Dyann F. Wirth, Modeling malaria genomics reveals transmission decline and rebound in Senegal Proceedings of the National Academy of Sciences of the United States of America. ,vol. 112, pp. 7067- 7072 ,(2015) , 10.1073/PNAS.1505691112
Sofía Mira‐Martínez, Núria Rovira‐Graells, Valerie M Crowley, Lindsey M Altenhofen, Manuel Llinás, Alfred Cortés, None, Epigenetic switches in clag3 genes mediate blasticidin S resistance in malaria parasites. Cellular Microbiology. ,vol. 15, pp. 1913- 1923 ,(2013) , 10.1111/CMI.12162
Michael T. Ferdig, Roland A. Cooper, Jianbing Mu, Bingbing Deng, Deirdre A. Joy, Xin-zhuan Su, Thomas E. Wellems, Dissecting the loci of low‐level quinine resistance in malaria parasites Molecular Microbiology. ,vol. 52, pp. 985- 997 ,(2004) , 10.1111/J.1365-2958.2004.04035.X
Adina Heinberg, Laura Kirkman, The molecular basis of antifolate resistance in Plasmodium falciparum: looking beyond point mutations Annals of the New York Academy of Sciences. ,vol. 1342, pp. 10- 18 ,(2015) , 10.1111/NYAS.12662
Amar Bir Singh Sidhu, Stephanie Gaw Valderramos, David A Fidock, None, pfmdr1 mutations contribute to quinine resistance and enhance mefloquine and artemisinin sensitivity in Plasmodium falciparum. Molecular Microbiology. ,vol. 57, pp. 913- 926 ,(2005) , 10.1111/J.1365-2958.2005.04729.X
Zenglei Wang, Yingna Wang, Mynthia Cabrera, Yanmei Zhang, Bhavna Gupta, Yanrui Wu, Karen Kemirembe, Yue Hu, Xiaoying Liang, Awtum Brashear, Sony Shrestha, Xiaolian Li, Jun Miao, Xiaodong Sun, Zhaoqing Yang, Liwang Cui, Artemisinin Resistance at the China-Myanmar Border and Association with Mutations in the K13 Propeller Gene Antimicrobial Agents and Chemotherapy. ,vol. 59, pp. 6952- 6959 ,(2015) , 10.1128/AAC.01255-15
Jianbing Mu, Michael T. Ferdig, Xiaorong Feng, Deirdre A. Joy, Junhui Duan, Tetsuya Furuya, G. Subramanian, L. Aravind, Roland A. Cooper, John C. Wootton, Momiao Xiong, Xin-zhuan Su, Multiple transporters associated with malaria parasite responses to chloroquine and quinine Molecular Microbiology. ,vol. 49, pp. 977- 989 ,(2003) , 10.1046/J.1365-2958.2003.03627.X
Jacob E. Lemieux, Sue A. Kyes, Thomas D. Otto, Avi I. Feller, Richard T. Eastman, Robert A. Pinches, Matthew Berriman, Xin‐zhuan Su, Chris I. Newbold, Genome-wide profiling of chromosome interactions in Plasmodium falciparum characterizes nuclear architecture and reconfigurations associated with antigenic variation. Molecular Microbiology. ,vol. 90, pp. 519- 537 ,(2013) , 10.1111/MMI.12381
Guillaume Lambert, Edo Kussell, Memory and Fitness Optimization of Bacteria under Fluctuating Environments PLoS Genetics. ,vol. 10, pp. e1004556- ,(2014) , 10.1371/JOURNAL.PGEN.1004556