The molecular basis of antifolate resistance in Plasmodium falciparum: looking beyond point mutations
作者： Adina Heinberg , Laura Kirkman
DOI: 10.1111/NYAS.12662
关键词:
摘要: … We will discuss the point mutations in target enzymes known to confer drug resistance and … Although increased gch1 expression enhanced pyrimethamine resistance in some parasite …
harvard.edu
sci-hub.se 参考文章(47)
Ping Wang, Qi Wang, Tanya V. Aspinall, Paul F. G. Sims, John E. Hyde, Transfection studies to explore essential folate metabolism and antifolate drug synergy in the human malaria parasite Plasmodium falciparum. Molecular Microbiology. ,vol. 51, pp. 1425- 1438 ,(2004) , 10.1111/J.1365-2958.2003.03915.X
Alissa Myrick, Anusha Munasinghe, Swati Patankar, Dyann F. Wirth, Mapping of the Plasmodium falciparum multidrug resistance gene 5′-upstream region, and evidence of induction of transcript levels by antimalarial drugs in chloroquine sensitive parasites Molecular Microbiology. ,vol. 49, pp. 671- 683 ,(2004) , 10.1046/J.1365-2958.2003.03597.X
Marna S. Costanzo, Kyle M. Brown, Daniel L. Hartl, Fitness Trade-Offs in the Evolution of Dihydrofolate Reductase and Drug Resistance in Plasmodium falciparum PLoS ONE. ,vol. 6, pp. e19636- ,(2011) , 10.1371/JOURNAL.PONE.0019636
Daria Van Tyne, Daniel J. Park, Stephen F. Schaffner, Daniel E. Neafsey, Elaine Angelino, Joseph F. Cortese, Kayla G. Barnes, David M. Rosen, Amanda K. Lukens, Rachel F. Daniels, Danny A. Milner, Charles A. Johnson, Ilya Shlyakhter, Sharon R. Grossman, Justin S. Becker, Daniel Yamins, Elinor K. Karlsson, Daouda Ndiaye, Ousmane Sarr, Souleymane Mboup, Christian Happi, Nicholas A. Furlotte, Eleazar Eskin, Hyun Min Kang, Daniel L. Hartl, Bruce W. Birren, Roger C. Wiegand, Eric S. Lander, Dyann F. Wirth, Sarah K. Volkman, Pardis C. Sabeti, Identification and Functional Validation of the Novel Antimalarial Resistance Locus PF10_0355 in Plasmodium falciparum PLoS Genetics. ,vol. 7, pp. e1001383- ,(2011) , 10.1371/JOURNAL.PGEN.1001383
S. Mharakurwa, T. Kumwenda, M. A. P. Mkulama, M. Musapa, S. Chishimba, C. J. Shiff, D. J. Sullivan, P. E. Thuma, K. Liu, P. Agre, Malaria antifolate resistance with contrasting Plasmodium falciparum dihydrofolate reductase (DHFR) polymorphisms in humans and Anopheles mosquitoes. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 108, pp. 18796- 18801 ,(2011) , 10.1073/PNAS.1116162108
Miriam K. Laufer, Phillip C. Thesing, Nicole D. Eddington, Rhoda Masonga, Fraction K. Dzinjalamala, Shannon L. Takala, Terrie E. Taylor, Christopher V. Plowe, Return of Chloroquine Antimalarial Efficacy in Malawi The New England Journal of Medicine. ,vol. 355, pp. 1959- 1966 ,(2006) , 10.1056/NEJMOA062032
J Enrique Salcedo-Sora, Edwin Ochong, Susan Beveridge, David Johnson, Alexis Nzila, Giancarlo A Biagini, Paul A Stocks, Paul M O'Neill, Sanjeev Krishna, Patrick G Bray, Stephen A Ward, None, The molecular basis of folate salvage in Plasmodium falciparum: characterization of two folate transporters. Journal of Biological Chemistry. ,vol. 286, pp. 44659- 44668 ,(2011) , 10.1074/JBC.M111.286054
P.K. Zhang, K. and Rathod, Divergent Regulation of Dihydrofolate Reductase Between Malaria Parasite and Human Host Science. ,vol. 296, pp. 545- 547 ,(2002) , 10.1126/SCIENCE.1068274
C. Wilson, A. Serrano, A Wasley, M. Bogenschutz, A. Shankar, D. Wirth, Amplification of a gene related to mammalian mdr genes in drug-resistant Plasmodium falciparum Science. ,vol. 244, pp. 1184- 1186 ,(1989) , 10.1126/SCIENCE.2658061
T. Hossain, I. Rosenberg, J. Selhub, G. Kishore, R. Beachy, K. Schubert, Enhancement of folates in plants through metabolic engineering Proceedings of the National Academy of Sciences of the United States of America. ,vol. 101, pp. 5158- 5163 ,(2004) , 10.1073/PNAS.0401342101