Chapter 2b Glycoproteins of parasites: Glycoconjugates of Leishmania
作者： Salvatore J. Turco
DOI: 10.1016/S0167-7306(08)60281-1
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摘要: Publisher Summary The striking ability of Leishmania parasites to survive in hostile environments with impunity throughout their life cycle has implicated the importance specialized glycoconjugates on surface. These are generally glycoproteins or complex carbohydrates anchored membrane by covalently-linked glycosylphosphatidylinositol (GPI). Lipophosphoglycan (LPG) is major cell surface glycoconjugate promastigote form parasite and believed be important for its uptake survival within macrophages. LPG consists four domains: (i) a phosphatidylinositol lipid anchor, (ii) glycan core, (iii) repeating saccharide-phosphate region, (iv) small oligosaccharide cap structure. Some functions that have been attributed related determined use LPG-defective mutants parasites. LPG- were selected based resistance agglutination cytotoxic lectin rich agglutinin. One ricin-resistant clone, named R2D2, was found completely defective synthesis expression LPG, due defect galactofuranose addition core region LPG. responsible protein R2D2 not yet precisely known, but either galactofuranosyltransferase an enzyme involved metabolism.
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