Inhibition of protein kinase C activity by the Leishmaniadonovani lipophosphoglycan

作者: Tessie B. McNeely , Salvatore J. Turco

DOI: 10.1016/0006-291X(87)90926-0

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摘要: Purified lipophosphoglycan from Leishmania donovani was found to inhibit the activity of protein kinase C isolated rat brain. Protein inhibition by continuous for 30 minutes. The glycoconjugate a competitive inhibitor with respect diolein, noncompetitive phosphatidylserine, and had no significant effect on M A. A possible physiological role as negative effector is suggested.

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