Ala54Thr Fatty Acid-Binding Protein 2 (FABP2) Polymorphism in Recurrent Depression: Associations with Fatty Acid Concentrations and Waist Circumference

摘要: BACKGROUND: Fatty acid (FA)-alterations may mediate the mutual association between Major Depressive Disorder (MDD) and cardiovascular disease (CVD). However, etiology of observed FA-alterations in MDD CVD remains largely unclear. An interesting candidate be a mutation fatty acid-binding protein 2 (FABP2)-gene, because it regulates dietary FA-uptake. Therefore, we aimed to test hypotheses that MDD-patients FABP2 Ala54Thr-polymorphism would (I) more prevalent than sex- age-matched controls, (II) associated with alterations FA-metabolism, (III) CVD-risk factor waist circumference. METHODS: We measured concentrations 29 different erythrocyte FAs, FABP2-genotype, circumference recurrent matched never-depressed controls. RESULTS: FABP2-genotype distribution did not significantly differ 137 73 patients had higher especially eicosadienoic (C20:2ω6; P=.009) other 20-carbon lower (P=.019). In addition, effects on seemed mediated by its effect C20:2ω6, from CONCLUSIONS: Although was MDD, our results indicate play role explanation MDD. For patients, potentially adaptive conversion increased bioavailable precursors into instead arachidonic might related low Because this is first investigation these associations, replication warranted, preferably nutrigenetic studies applying lipidomics detailed assessment.