Microenvironmental Cues Determine Tumor Cell Susceptibility to Neutrophil Cytotoxicity.

摘要: We have recently shown that neutrophil antitumor cytotoxicity is Ca2+ dependent and mediated by TRPM2, an H2O2-dependent channel. However, activity on context manifested in the premetastatic niche, but not at primary site. therefore hypothesized expression of TRPM2 consequent susceptibility to may be associated with epithelial/mesenchymal cellular state. found was upregulated during epithelial-to-mesenchymal transition (EMT), mesenchymal cells were more susceptible cytotoxicity. Conversely, undergoing mesenchymal-to-epithelial (MET) expressed reduced levels rendering them resistant Cells expressing protected from seeded efficiently lung. These data identify as link between environmental cues tumor site, cell cytotoxicity, disease progression. Furthermore, these EMT a process enhancing tumor-cell immune and, contrast, MET novel mode evasion.Significance: required for metastatic spread concomitantly enhances Cancer Res; 78(17); 5050-9. ©2018 AACR.