Neutrophils: Orchestrators of the Malignant Phenotype

摘要: Neutrophils are the first leukocytes recruited to sites of inflammation, where they execute anti-microbial functions eliminate infectious agents. These include phagocytosis, release reactive oxygen species and formation neutrophil extracellular traps via NETosis. receiving increasing attention in context cancer, these same neutrophil-associated also important for modulating tumor growth metastatic progression. phenotypically heterogeneous and, depending on context, exert anti- or pro-tumorigenic functions. Increasing evidence suggests an role neutrophils their involvement promoting multiple steps cascade. The include: (1) local invasion intravasation cancer cells into circulation, (2) survival bloodstream extravasation at a distant site, (3) early cell seeding/survival, (4) progressive form macroscopic metastases. Although designed agents can cells, dysregulation promote enable metastasis along In this review, we will provide overview current advances biology cancer. We discuss emerging field immunometabolism, which rewiring alternative metabolic pathways within impact pro-tumorigenic/pro-metastatic