Non-invasive diagnosis of liver diseases by breath analysis using an optimized ion-molecule reaction-mass spectrometry approach: a pilot study.
作者： Gunda Millonig , Siegfried Praun , Michael Netzer , Christian Baumgartner , Albert Dornauer
DOI: 10.3109/13547501003624512
关键词:
摘要: Breath composition is altered in liver diseases. We tested if ion–molecule-reaction mass spectrometry (IMR-MS) combined with a new statistical modality improves the diagnostic accuracy of breath analysis analysed 114 molecules 126 individuals (healthy controls, and patients non-alcoholic alcoholic fatty disease cirrhosis) by IMR-MS. Characteristic exhalation patterns were identified for each group. Combining two to seven stacked feature ranking model reached (area under curve) individual diseases between 0.88 0.97. IMR-MS followed sophisticated promising tool diagnostics analysis.
informahealthcare.com参考文章(38)
Steven L. Salzberg, Alberto Segre, Programs for Machine Learning ,(1994)
Igor Kononenko, Estimating attributes: analysis and extensions of RELIEF european conference on machine learning. pp. 171- 182 ,(1994) , 10.1007/3-540-57868-4_57
A. Jordan, A. Hansel, R. Holzinger, W. Lindinger, Acetonitrile and benzene in the breath of smokers and non-smokers investigated by proton transfer reaction mass spectrometry (PTR-MS) International Journal of Mass Spectrometry and Ion Processes. ,vol. 148, ,(1995) , 10.1016/0168-1176(95)04236-E
Ying Wang, Gunda Millonig, Jagadeesan Nair, Eleonora Patsenker, Felix Stickel, Sebastian Mueller, Helmut Bartsch, Helmut K. Seitz, Ethanol‐induced cytochrome P4502E1 causes carcinogenic etheno‐DNA lesions in alcoholic liver disease Hepatology. ,vol. 50, pp. 453- 461 ,(2009) , 10.1002/HEP.22978
A. A. Nanji, U. Khettry, S. M. H. Sadrzadeh, Lactobacillus feeding reduces endotoxemia and severity of experimental alcoholic liver (disease). Experimental Biology and Medicine. ,vol. 205, pp. 243- 247 ,(1994) , 10.3181/00379727-205-43703
Toru Takahashi, Jerome M. Lasker, Alan S. Rosman, Charles S. Lieber, Induction of cytochrome P-4502E1 in the human liver by ethanol is caused by a corresponding increase in encoding messenger RNA. Hepatology. ,vol. 17, pp. 236- 245 ,(1993) , 10.1002/HEP.1840170213
Reijo Takalo, Päivi Piirilä, Anssi R. A. Sovijärvi, Repeatability of successive measurements with a portable nitric oxide analyser in patients with suggested or diagnosed asthma Scandinavian Journal of Clinical & Laboratory Investigation. ,vol. 68, pp. 830- 832 ,(2008) , 10.1080/00365510802621158
U. Tegtmeyer, H. P. Weiss, R. Schl�gl, Gas analysis by IMR-MS : a comparison to conventional mass spectrometry Fresenius Journal of Analytical Chemistry. ,vol. 347, pp. 263- 268 ,(1993) , 10.1007/BF00323969
Peter J. Mazzone, Analysis of Volatile Organic Compounds in the Exhaled Breath for the Diagnosis of Lung Cancer Journal of Thoracic Oncology. ,vol. 3, pp. 774- 780 ,(2008) , 10.1097/JTO.0B013E31817C7439
Bradford G. Stone, Timothy J. Besse, William C. Duane, C. Dean Evans, Eugene G. DeMaster, Effect of regulating cholesterol biosynthesis on breath isoprene excretion in men Lipids. ,vol. 28, pp. 705- 708 ,(1993) , 10.1007/BF02535990