XRCC1 polymorphism and lung cancer risk in relation to tobacco smoking.

摘要: DNA repair plays a critical role in protecting the genome of cell from carcinogens or ionising radiation. Reduced DNA-repair capacity can increase susceptibility to occupational-induced cancer. Three coding polymorphisms at codons 194, 280, and 399 X-ray cross complementing group 1 (XRCC1) gene have been identified, it is possible that these may affect DNA- thus modulate cancer susceptibility. In current German study, we investigated XRCC1-polymorphisms as genetic modifier risk for individuals with lung susceptible genotypes, especially relation tobacco smoking. polymorphisms; XRCC1 Arg194Trp, Arg280His Arg399Gln, were determined by real-time PCR analysis 446 patients 622 controls. The observed allele frequencies population within range described Caucasians. Multivariate analyses who carried least one mutant variant Arg194Trp (OR=1.03; 95%-CI: 0.66-1.61), (OR=0.95; 0.57-1.60), Arg399Gln (OR=0.99 CI: 0.73-1.34), did not show any elevated risks. When analysed histology, no individual subtype was significantly associated polymorphisms. Lung rose higher cumulative cigarette consumption. Stratified between smoking genotypes revealed increasing risks heavy smokers (>60 pack-years), presence copy (OR=79.29; 8.53-737.04) (OR=61.87; 15.65-244.67). By analysing interaction combined having joint effect. this Arg280His, Arg399Gln-polymorphisms, had relevant modifying effect on dose.