No association between XRCC1 gene Arg194Trp polymorphism and risk of lung cancer: evidence based on an updated cumulative meta-analysis
作者： Jing Zhang , Xian-Tao Zeng , Jun-Rong Lei , Yi-Jun Tang , Jiong Yang
DOI: 10.1007/S13277-014-1745-Z
关键词: Lung cancer 、 Evidence-based practice 、 Biology 、 Odds ratio 、 XRCC1 、 Oncology 、 Case-control study 、 Publication bias 、 Meta-analysis 、 Bioinformatics 、 Internal medicine 、 Confidence interval
摘要: X-ray repair cross-complementing group 1 (XRCC1) gene Arg194Trp polymorphism has been reported to be associated with risk of lung cancer in many published studies. Nevertheless, the research results were inconclusive and conflicting. To reach conclusive results, several meta-analysis studies conducted by combining from literature reports through pooling analysis. However, these previous still not consistent. Hence, we used an updated cumulative get a more comprehensive precise result 25 case–control searching PubMed database up September 1, 2013. The was carried out Comprehensive Meta-Analysis software odds ratio (OR) 95 % confidence interval (CI) estimate pooled effect. involving 8,876 patients 11,210 controls revealed that XRCC1 [(OR = 0.97, 95 %CI = 0.92–1.03) for Trp vs. Arg; (OR = 0.92, CI = 0.85–0.98) ArgTrp ArgArg; (OR = 1.07, CI = 0.92–1.23) TrpTrp (OR = 0.93, CI = 0.87–1.00) (TrpTrp + ArgTrp) (OR = 1.08, CI = 0.94–1.25) (ArgTrp + ArgArg)]. showed maintained same, while ORs CI stable accumulation sensitivity subgroups analyses robust affected any single study no publication bias. Relevant might needed supporting results.
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