Portal capillary C4d deposits and increased infiltration by macrophages indicate humorally mediated mechanisms in acute cellular liver allograft rejection.
作者： Anja Dankof , Maximilian Schmeding , Lars Morawietz , Raphaela Günther , Manfred G. Krukemeyer
DOI: 10.1007/S00428-005-1245-Z
关键词:
摘要: Almost no data exist concerning the role of antibody-mediated mechanisms in human acute cellular liver allograft rejection (ACR). Therefore, aim this study was to determine whether ACR is associated with depositions complement split products and increased infiltration by B-lymphocytes, plasma cells macrophages. A total 35 biopsy specimens (ACR n=22, controls n=13) were analyzed immunohistochemical single double staining. The average numbers CD20+, CD38+ CD68+ per portal tract established while presence C4d C3d deposits evaluated semiquantitatively. Significantly greater CD20+ (P=0.029) (P=0.014) found than control specimens. Additionally, 50% patients diagnosed showed along capillaries, which a significantly macrophages (P=0.007). Taken together these results support involvement humorally mediated some cases ACR.
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