Macrolide‐associated sensorineural hearing loss: A systematic review

摘要: Objectives To investigate the potential association of macrolide antibiotics with sensorineural hearing loss (SNHL) and which agents dosage may be related. To evaluate whether an optimal treatment exists for reversing SNHL that occurs after therapy. Study Design Systematic review literature. Methods Computerized (PubMed, EMBASE, Cochrane Library) manual searches were performed to identify human studies all ages (patients) who received macrolides (intervention, or without control) documented (outcome). All study designs assessed. Extracted data included regimen details, as well timing, severity, reversibility drug cessation alone additional medical intervention. Study associated risk bias assessed. Results The 44 publications (3 prospective, 41 retrospective) met these criteria described 78 cases audiometrically confirmed SNHL. was oral intravenous administration at standard elevated doses. irreversible in six cases, despite (n = 5) steroid 1). Irreversible observed following 2 3 days exposure. reversible 70 cases. In two coupled restored hearing. Reversible improved within hours days. Nine also 42 subjective patient-reported loss. Limitations arose from design, related comorbidities, concomitant administration. Conclusion SNHL follow exposure, even Further research is needed understand incidence, prevalence, biological mechanism its ototoxicity. Laryngoscope, 128:228–236, 2018