Multiple Genetic Alterations and Abnormal Growth Factor Network in Human Esophageal Carcinomas
作者： Kazuhiro Yoshida , Wataru Yasui , Yoshihiro Kagawa , Eiichi Tahara
DOI: 10.1007/978-4-431-65915-0_4
关键词:
摘要: Esophageal carcinoma is the most malignant gastrointestinal neoplasm. Multiple genetic alterations of oncogenes and tumor suppressor genes take place in esophageal squamous cell carcinomas. Co-amplification cyclin D1, hst-1, int-2 gene found 40% primary tumors almost all metastatic tumors. The prognosis patient with amplification evidently poorer than those without amplification. negative cycle regulators, including p.53 gene, Rb BRCA1 p16 (MTS1), p15 (MTS2), p21 (WAF1/CIP1), play an important role development progression Furthermore, multiple growth factor—receptor loops exist participate autocrine cancer. They include epidermal factor (EGF), transforming factors (TGF) a β, platelet-derived (PDGF). Overexpression EGF, TGF-α, EGFR closely correlated behavior cells prognosis. These stimulate production interstitial degradation enzymes down-regulation Ecadherin function, which may lead to invasion metastasis.
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