Molecular-pathological diagnosis of gastrointestinal tissues and its contribution to cancer histopathology.

摘要: Multiple genetic and epigenetic alterations of cancer-related genes molecules are involved in the course development progression gastrointestinal cancers. These include telomerase activation, instability, abnormalities oncogenes, tumor suppressor genes, cell cycle regulators, adhesion DNA repair genes. By analyzing these pathology specimens, we can improve differential diagnosis cancer, obtain information grade malignancy, identify patients at high risk for developing multiple primary Since 1993, a system molecular-pathological was established, has been performed as routine service collaboration with Hiroshima City Medical Association Clinical Laboratory. More than 10 000 cases biopsy surgery have analyzed, additional diagnosis, biological malignancy multiplicity could be obtained. Molecular-pathological may provide new approach to cancer novel therapeutics 21st century. Furthermore, analysis clinical materials clarify molecular mechanism carcinogenesis comparative morphological changes. From analyses p27KIP1 adenomas, learned that abnormality nucleus is an indicator cells immortality malignant potential must participate super-early (detection true precancerous lesions) cancer. thus contributes detailed understanding histopathology improves histopathological diagnosis.