Discovery of human zinc deficiency: 50 years later.

摘要: Essentiality of zinc for humans and its deficiency was recognized in 1963. During the past 50 years, it has become apparent that is prevalent. Nutritional may affect nearly 2 billion subjects developing world. Consumption cereal proteins high phytate decreases availability absorption. Conditioned also very common. Growth retardation, hypogonadism males, rough skin, impaired immunity, neuro-sensory disorder cognitive impairment are some clinical manifestations deficiency. Zinc involved many biochemical functions. Over 300 enzymes require their activation 2000 transcription factors gene expression. essential cell mediated immunity. an effective antioxidant anti-inflammatory agent. In therapeutic dosages, been used treatment acute diarrhea infants children, common cold, Wilson's disease, sickle disease prevention blindness patients with age related macular degeneration.