Atsdr Evaluation of Health Effects of Chemicals. Iv. Polycyclic Aromatic Hydrocarbons (PAHs): Understanding a Complex Problem:

摘要: Polycyclic Aromatic Hydrocarbons (PAHs) are a group of chemicals that formed during the incomplete burning coal, oil, gas, wood, garbage, or other organic substances, such as tobacco and charbroiled meat. There more than 100 PAHs. PAHs generally occur complex mixtures (for example, part products soot), not single compounds. found throughout environment in air, water, soil. As its mandate, Agency for Toxic Substances Disease Registry (ATSDR) prepares toxicological profiles on hazardous chemicals, including (ATSDR, 1995), at facilities Comprehensive Environmental Response, Compensation, Liability Act (CERCLA) National Priorities List (NPL) which pose most significant potential threat to human health, determined by ATSDR Protection (EPA). These include information health effects from different routes durations exposure, their regulations advisories, adequacy existing database. Assessing is major challenge because environmental exposures these usually with chemicals. The biological consequences exposure depend toxicity, carcinogenic noncarcinogenic, individual components mixture, types interactions among them, confounding factors thoroughly understood. Also identified research needed will allow estimation realistic risks posed assessment component should focus (1) development reliable analytical methods determination bioavailable following ingestion, (2) media, particularly particle-bound PAHs, (3) data ambient levels metabolites tissues/fluids control populations, (4) need critical evaluation current media waste sites. obtaining noncarcinogenic humans, toxicokinetics. This report provides excerpts profile 1995) contains detailed information.