Differential capacities of CD4+, CD8+, and CD4-CD8- T cell subsets to express IL-18 receptor and produce IFN-gamma in response to IL-18.
作者： Masashi Kurimoto , Steven Clark , Hyun-Jong Ahn , Xu-Yu Zhou , Jie Mu
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摘要: IL-12 and IL-18 have the capacity to stimulate IFN-gamma production by T cells. Using a cell clone, we reported that responsiveness is generated only after exposure IL-12. Here, investigated induction of in resting CD8+, CD4+, CD4-CD8- Resting cells respond neither nor IL-18. After stimulation with anti-CD3 plus anti-CD28 mAbs, expressed IL-12R, but not IL-18R, produced response Cultures anti-CD3/anti-CD28 presence rIL-12 induced IL-18R expression IL-18-stimulated production, which reached higher levels than stimulation. However, there was substantial difference among subsets. CD4+ marginal small amounts IFN-gamma, whereas CD8+ more Moreover, comparable those for one order did These results indicate represents mechanism underlying enhanced cells, operation this differs depending on subset stimulated.
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