A series of immune responses leading to the induction ofT cell IL-12/IL-18 responsiveness in patientswith relatively large tumor burdens

摘要: The induction of interleukin-12 (IL-12) responsiveness in T cells depends on cell receptor (TCR) triggering, and is regarded as a parameter recently TCR-sensitized cells. Here, we investigated whether IL-12 could be detected freshly prepared from tumor-bearing patients, if so such patients exhibited additional immunological parameters related to responsiveness. CD4+ CD8+ populations an appreciable proportion high levels evaluated by IL-12-stimulated interferon-gamma (IFN-γ) production. with were observed the group moderate large tumor mass or metastases rather than small tumors. frequency population was also lower post-surgery tumor-free showing correlation between presence certain extent burden. More importantly, higher incidence exhibiting detectable plasma levels, correlated IL-18 induced TCR triggering subsequent stimulation respectively. Furthermore, TCR-triggered stimulate antigen-presenting (APC) produce IL-12. Therefore, present observations suggest that immune response loop sensitization IL-12/IL-18 via production operates particularly those relatively burdens.