Low Density Lipoprotein Apheresis Ameliorates Interferon-γ Production in Patients With Nephrotic Syndrome
作者： Eri Muso , Hitomi Miyata , Kazuko Uno , Takahiko Ono , Masatomo Yashiro
DOI: 10.1111/J.1744-9987.2011.01045.X
关键词:
摘要: Rapid amelioration of hypercholesterolemia in nephrotic syndrome (NS) using low density lipoprotein-apheresis (LDL-A) sometimes leads to NS remission, along with improvement impaired biodefense system; however, the mechanism how LDL-A affects is still unknown. We studied IFN-γ production under IL-12 stimulation for 24 h whole blood from 30 patients, 31 non-NS 35 healthy volunteers and another four persistent patients due refractory focal segmental glomerulonephritis minimal change type syndrome. compared peripheral mononuclear cells (PBMC) before after each 14 procedures. Finally, we effect that patients' serum had on volunteers' PBMC. Whole was significantly lower or patients. In NS, LDL-A, returned normal levels. PBMC varied greatly among these did not show consistent changes LDL-A. Healthy incubated obtained LDLA showed higher than if a patient state. might restore suppressed function thereby ameliorating state, possibly through removing interfering factors.
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