Food Shortage Causes Differential Effects on Body Composition and Tissue-Specific Gene Expression in Salmon Modified for Increased Growth Hormone Production

摘要: Growth hormone (GH) transgenic salmon possesses markedly increased metabolic rate, appetite, and feed conversion efficiency, as well an ability to compete for food resources. Thus, the of GH-transgenic fish withstand periods deprivation occurs in nature is potentially different than that nontransgenic fish. However, physiological genetic effects GH production over long remain largely unknown. Here, coho (Oncorhynchus kisutch) nontransgenic, wild-type were subjected a 3-month trial, during which time performance characteristics related growth measured along with proximate compositions. To examine potential GH-transgenesis on long-term deprivation, group genes muscle development liver metabolism was selected quantitative PCR analysis. Results showed lose weight at rate compared even though compositions remained relatively similar between groups. A total nine physiology (cathepsin, cee, insulin-like factor, myostatin, murf-1, myosin, myogenin, proteasome delta, tumor necrosis factor) five (carnitine palmitoyltransferase, fatty acid synthase, glucose-6-phosphatase, glucose-6-phosphate dehydrogenase, glucokinase) shown be differentially regulated time. These responses assist identifying differences relation fitness arising from elevated shortage.