The mouse type IV c-abl gene product is a nuclear protein, and activation of transforming ability is associated with cytoplasmic localization
作者： Richard A. Van Etten , Peter Jackson , David Baltimore
DOI: 10.1016/0092-8674(89)90102-5
关键词:
摘要: The subcellular localization of the mouse type IV c-abl protein was determined by indirect immunofluorescence nontransformed NIH 3T3 fibroblasts that overexpress protein. Unlike viral transforming p160gag/v-abl, which has cytoplasmic and plasma membrane localization, a large fraction (IV) is nuclear, with remainder in cytoplasm membrane. Deletion small N-terminal regulatory region protein, sufficient to activate its potential fully, changes distribution from nucleus cytoplasm. Mapping an amino acid sequence responsible for nuclear reveals signal similar SV40 T antigen.
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