The dispersion of repolarization in patients with ventricular tachycardia. A study using simultaneous monophasic action potential recordings from two sites in the right ventricle

摘要: The role of increased dispersion repolarization in the genesis torsade de pointes and ventricular fibrillation has been well recognized generally, but not monomorphic tachycardia (VT). Monophasic action potentials (MAP) were therefore recorded simultaneously from right (RV) apex (RVA) outflow tract (RVOT) during sinus rhythm, RV pacing programmed extra stimulation (PES) 24 patients with VT. activation time (AT), MAP duration at 90% (MAPd), (RT) measured their dispersions, defined as differences these parameters between RVA RVOT, calculated. During rhythm pacing, dispersions AT, MAPd RT (dispersions) significantly larger 17 a VT induced than those without. PES, further augmented S2 beats seven sustained induced, maximal being 85 +/- 22 ms. Both AT that contributed to RT. In both our two recording, marked increase (140 190 ms, respectively) was observed immediately before initiation A link inducibility found patients, which suggests play an important