摘要: Since it was identified a decade ago, cyclin-dependent kinase 5 (CDK5) has emerged as crucial regulator of neuronal migration in the developing central nervous system. CDK5 phosphorylates diverse list substrates, implicating regulation range cellular processes - from adhesion and motility, to synaptic plasticity drug addiction. Recent evidence indicates that deregulation this is involved pathology neurodegenerative diseases.
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Matthew Meyerson, Greg H Enders, Chin-Lee Wu, LK Su, C Gorka, C Nelson, Ed Harlow, LH Tsai, A family of human cdc2-related protein kinases. The EMBO Journal. ,vol. 11, pp. 2909- 2917 ,(1992) , 10.1002/J.1460-2075.1992.TB05360.X
Jean-Pierre Julien, Amyotrophic Lateral Sclerosis: Unfolding the Toxicity of the Misfolded Cell. ,vol. 104, pp. 581- 591 ,(2001) , 10.1016/S0092-8674(01)00244-6
Jason Moffat, Dongqing Huang, Brenda Andrews, Functions of Pho85 cyclin-dependent kinases in budding yeast Progress in Cell Cycle Research. ,vol. 4, pp. 97- 106 ,(2000) , 10.1007/978-1-4615-4253-7_9
Zhong Qi, Qi-Quan Huang, Ki-Young Lee, John Lew, Jerry H. Wang, Reconstitution of Neuronal Cdc2-like Kinase from Bacteria-expressed Cdk5 and an Active Fragment of the Brain-specific Activator Journal of Biological Chemistry. ,vol. 270, pp. 10847- 10854 ,(1995) , 10.1074/JBC.270.18.10847
IVANA DELALLE, PRADEEP G BHIDE, VERNE S CAVINESS JR, LI-HUEI TSAI, TEMPORAL AND SPATIAL PATTERNS OF EXPRESSION OF P35, A REGULATORY SUBUNIT OF CYCLIN-DEPENDENT KINASE 5, IN THE NERVOUS SYSTEM OF THE MOUSE Journal of Neurocytology. ,vol. 26, pp. 283- 296 ,(1997) , 10.1023/A:1018500617374
J Lew, R.J. Winkfein, H.K. Paudel, J.H. Wang, Brain proline-directed protein kinase is a neurofilament kinase which displays high sequence homology to p34cdc2. Journal of Biological Chemistry. ,vol. 267, pp. 25922- 25926 ,(1992) , 10.1016/S0021-9258(18)35696-5
Takeshi Harada, Takaya Morooka, Satoshi Ogawa, Eisuke Nishida, ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1 Nature Cell Biology. ,vol. 3, pp. 453- 459 ,(2001) , 10.1038/35074516
FATHEL RAHMAN M MUSA, IKUMASA TAKENAKA, RYOJI KONISHI, MASAAKI TOKUDA, None, Effects of luteinizing hormone, follicle-stimulating hormone, and epidermal growth factor on expression and kinase activity of cyclin-dependent kinase 5 in Leydig TM3 and Sertoli TM4 cell lines. Journal of Andrology. ,vol. 21, pp. 392- 402 ,(2000) , 10.1002/J.1939-4640.2000.TB03393.X
Amy KY Fu, Wing-Yu Fu, Janet Cheung, Karl WK Tsim, Fanny CF Ip, Jerry H Wang, Nancy Y Ip, None, Cdk5 is involved in neuregulin-induced AChR expression at the neuromuscular junction. Nature Neuroscience. ,vol. 4, pp. 374- 381 ,(2001) , 10.1038/86019
Edward C Gilmore, Toshio Ohshima, André M Goffinet, Ashok B Kulkarni, Karl Herrup, None, Cyclin-Dependent Kinase 5-Deficient Mice Demonstrate Novel Developmental Arrest in Cerebral Cortex The Journal of Neuroscience. ,vol. 18, pp. 6370- 6377 ,(1998) , 10.1523/JNEUROSCI.18-16-06370.1998