Schistosoma mansoni : structural and biophysical aspects of Lewis X-antibody interactions

摘要: Schistosomiasis (Bilharzia) is a tropical parasitic disease caused by schistosomes. At present more than 200 million people are infected these parasites. If the infection left untreated, parasites can survive within body for 5 years or more. The parasite has developed r escape mechanisms to immune response of its host. production heavily glycosylated proteins and lipids thought play an important role in this. One carbohydrate structure expressed all stages trisaccharide Lewis X (Le^x). By measuring interaction with mono-, di-, trimeric Lex antibodies both vitro vivo it become clear that humoral various oligomeric forms Le^x different. This now be taken into account further studies which cellular immunogenicity investigated. Next, elucidation crystal monoclonal antibody complex led better insight protein-carbohydrage interactions on molecular level. new knowledge used improvement diagnostic techniques schistosomiasis, also understanding this other diseases plays (e.g. cancer).