miR-938 promotes colorectal cancer cell proliferation via targeting tumor suppressor PHLPP2
作者： Chang-Feng Li , Yong-Chao Li , Jing-Peng Jin , Zhen-Kun Yan , Dan-Dan Li
DOI: 10.1016/J.EJPHAR.2017.04.023
关键词:
摘要: Abstract Colorectal cancer (CRC) is one of the leading causes cancer-related deaths worldwide. Although development therapy approaches, outcome CRC patients still poor, understanding biological mechanism progression critical to improve treatment strategies. miRNAs regulate progression, we found miR-938 was upregulated in tissues and cells, MTT assay, colony formation assay soft agar growth suggested overexpression promoted cell proliferation, knockdown inhibited proliferation. Tumor suppressor PH domain Leucine-rich-repeats Protein Phosphatase 2 (PHLPP2) a target miR-938, PHLPP2, luciferase activity directly bound 3′UTR meanwhile, c-Myc Cyclin D1 expression, confirming Double PHLPP2 suggesting proliferation by inhibiting PHLPP2.
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sci-hub.se 参考文章(23)
Nitin Kumar Agarwal, Xiaoping Zhu, Mihai Gagea, Charles L. White, Gilbert Cote, Maria-Magdalena Georgescu, PHLPP2 suppresses the NF-κB pathway by inactivating IKKβ kinase Oncotarget. ,vol. 5, pp. 815- 823 ,(2014) , 10.18632/ONCOTARGET.1774
Kenneth K.W. To, W.W. Leung, Simon S.M. Ng, Exploiting a novel miR-519c-HuR-ABCG2 regulatory pathway to overcome chemoresistance in colorectal cancer. Experimental Cell Research. ,vol. 338, pp. 222- 231 ,(2015) , 10.1016/J.YEXCR.2015.09.011
Chang-feng Li, Yong-chao Li, Li-bo Chen, Dan-dan Li, Lei Yang, Jing-peng Jin, Bin Zhang, MicroRNA-766 targeting regulation of SOX6 expression promoted cell proliferation of human colorectal cancer. OncoTargets and Therapy. ,vol. 8, pp. 2981- 2988 ,(2015) , 10.2147/OTT.S89459
Rongpan Bai, Chunhua Weng, Haojie Dong, Siqi Li, Guangdi Chen, Zhengping Xu, MicroRNA-409-3p suppresses colorectal cancer invasion and metastasis partly by targeting GAB1 expression International Journal of Cancer. ,vol. 137, pp. 2310- 2322 ,(2015) , 10.1002/IJC.29607
Henriett Butz, István Likó, Sándor Czirják, Péter Igaz, Márta Korbonits, Károly Rácz, Attila Patócs, MicroRNA profile indicates downregulation of the TGFβ pathway in sporadic non-functioning pituitary adenomas Pituitary. ,vol. 14, pp. 112- 124 ,(2011) , 10.1007/S11102-010-0268-X
John Brognard, Emma Sierecki, Tianyan Gao, Alexandra C. Newton, PHLPP and a Second Isoform, PHLPP2, Differentially Attenuate the Amplitude of Akt Signaling by Regulating Distinct Akt Isoforms Molecular Cell. ,vol. 25, pp. 917- 931 ,(2007) , 10.1016/J.MOLCEL.2007.02.017
J Liu, H L Weiss, P Rychahou, L N Jackson, B M Evers, T Gao, Loss of PHLPP expression in colon cancer: role in proliferation and tumorigenesis. Oncogene. ,vol. 28, pp. 994- 1004 ,(2009) , 10.1038/ONC.2008.450
M. Liu, A. Roth, M. Yu, R. Morris, F. Bersani, M. N. Rivera, J. Lu, T. Shioda, S. Vasudevan, S. Ramaswamy, S. Maheswaran, S. Diederichs, D. A. Haber, The IGF2 intronic miR-483 selectively enhances transcription from IGF2 fetal promoters and enhances tumorigenesis Genes & Development. ,vol. 27, pp. 2543- 2548 ,(2013) , 10.1101/GAD.224170.113
Jingpeng Jin, Shanshan Zhou, Changfeng Li, Ruisi Xu, Lingling Zu, Jiacong You, Bin Zhang, MiR-517a-3p accelerates lung cancer cell proliferation and invasion through inhibiting FOXJ3 expression Life Sciences. ,vol. 108, pp. 48- 53 ,(2014) , 10.1016/J.LFS.2014.05.006
Ulf Andersson Ørom, Finn Cilius Nielsen, Anders H. Lund, MicroRNA-10a Binds the 5′UTR of Ribosomal Protein mRNAs and Enhances Their Translation Molecular Cell. ,vol. 30, pp. 460- 471 ,(2008) , 10.1016/J.MOLCEL.2008.05.001