Downregulated miR-217 expression predicts a poor outcome in acute myeloid leukemia.
作者： Jinhua Yan , Guohe Wu , Jianlan Chen , Lifang Xiong , Guoan Chen
DOI: 10.3233/CBM-170936
关键词:
摘要: BACKGROUND Circulating microRNAs (miRNAs) play an essential role in the development and progression of acute myeloid leukemia (AML). However, clinical value serum miR-217 AML remained poorly known. OBJECTIVE This study aimed to explore significance AML. METHODS Quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR) was performed detect levels blood samples obtained from 89 patients 60 healthy controls. RESULTS The results showed that expression significantly decreased compared Likewise, were greatly downregulated with poor risk cytogenetic. ROC analysis demonstrated could effectively differentiate normal Also, markedly increased achieving complete remission after their treatment. In addition, low associated aggressive features. Moreover, Kaplan-Meier tended have shorter overall survival disease free survival. multivariate stratified for prognostic parameters, proved be independent indicator. CONCLUSIONS Collectively, identified as marker diagnosis prognosis
sci-hub.se 参考文章(20)
David P Bartel, MicroRNAs: Genomics, Biogenesis, Mechanism, and Function Cell. ,vol. 116, pp. 281- 297 ,(2004) , 10.1016/S0092-8674(04)00045-5
Hui Wang, Xiaolin Dong, Xin Gu, Rong Qin, Hongping Jia, Jianpeng Gao, The MicroRNA-217 Functions as a Potential Tumor Suppressor in Gastric Cancer by Targeting GPC5 PLOS ONE. ,vol. 10, pp. e0125474- ,(2015) , 10.1371/JOURNAL.PONE.0125474
Dong-liang Chen, Dong-sheng Zhang, Yun-xin Lu, Le-zong Chen, Zhao-lei Zeng, Ming-ming He, Feng-hua Wang, Yu-hong Li, Hui-zhong Zhang, Helene Pelicano, Wei Zhang, Rui-hua Xu, microRNA-217 inhibits tumor progression and metastasis by downregulating EZH2 and predicts favorable prognosis in gastric cancer Oncotarget. ,vol. 6, pp. 10868- 10879 ,(2015) , 10.18632/ONCOTARGET.3451
Junhua Guo, Zhijun Feng, Zhi’ang Huang, Hongyan Wang, Wujie Lu, MicroRNA-217 functions as a tumour suppressor gene and correlates with cell resistance to cisplatin in lung cancer. Molecules and Cells. ,vol. 37, pp. 664- 671 ,(2014) , 10.14348/MOLCELLS.2014.0121
Martin S. Tallman, D. Gary Gilliland, Jacob M. Rowe, Drug therapy for acute myeloid leukemia. Blood. ,vol. 106, pp. 1154- 1163 ,(2005) , 10.1182/BLOOD-2005-01-0178
Daniel G. Tenen, Disruption of differentiation in human cancer: AML shows the way Nature Reviews Cancer. ,vol. 3, pp. 89- 101 ,(2003) , 10.1038/NRC989
A E Szafranska, T S Davison, J John, T Cannon, B Sipos, A Maghnouj, E Labourier, S A Hahn, MicroRNA expression alterations are linked to tumorigenesis and non-neoplastic processes in pancreatic ductal adenocarcinoma. Oncogene. ,vol. 26, pp. 4442- 4452 ,(2007) , 10.1038/SJ.ONC.1210228
Shichang Deng, Shuai Zhu, Bo Wang, Xiang Li, Yang Liu, Qi Qin, Qiong Gong, Yi Niu, Cheng Xiang, Jingyuan Chen, Jin Yan, Shijiang Deng, Tao Yin, Ming Yang, Heshui Wu, Chunyou Wang, Gang Zhao, None, Chronic pancreatitis and pancreatic cancer demonstrate active epithelial-mesenchymal transition profile, regulated by miR-217-SIRT1 pathway. Cancer Letters. ,vol. 355, pp. 184- 191 ,(2014) , 10.1016/J.CANLET.2014.08.007
Petra Vychytilova-Faltejskova, Igor Kiss, Sona Klusova, Jan Hlavsa, Vladimir Prochazka, Zdenek Kala, Jan Mazanec, Jitka Hausnerova, Leos Kren, Marketa Hermanova, Jiri Lenz, Petr Karasek, Rostislav Vyzula, Ondrej Slaby, MiR-21, miR-34a, miR-198 and miR-217 as diagnostic and prognostic biomarkers for chronic pancreatitis and pancreatic ductal adenocarcinoma Diagnostic Pathology. ,vol. 10, pp. 38- 38 ,(2015) , 10.1186/S13000-015-0272-6
Alan Burnett, Meir Wetzler, Bob Löwenberg, Therapeutic Advances in Acute Myeloid Leukemia Journal of Clinical Oncology. ,vol. 29, pp. 487- 494 ,(2011) , 10.1200/JCO.2010.30.1820