ROLE OF C-KIT RECEPTOR TYROSINE KINASE IN THE DEVELOPMENT, SURVIVAL AND NEOPLASTIC TRANSFORMATION OF MAST CELLS
作者： Tohru Tsujimura
DOI: 10.1111/J.1440-1827.1996.TB03571.X
关键词:
摘要: The c-kit gene is allelic with the dominant spotting (W) locus on mouse chromosome 5 and encodes a receptor tyrosine kinase. llgand for c-klt stem cell factor (SCF), which principal growth mast cells. loss-of-function mutations of affect development cells, thereby resulting in depletion abundant expression c-ktt indispensable survival In addition, galn-of-function were found several tumor lines. When these introduced to cells murine interleukin (IL)-3-dependent lines, constitutive kinase activity not only abrogated IL-3 requirement but also caused them become tumorlgenic nude athymic mice. gain-of-function appear result malignant transformation Taken together, signals from are essential development, survival,
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