Detecting temporal and spatial effects of epithelial cancers with Raman spectroscopy

作者: Matthew D Keller , Elizabeth M Kanter , Chad A Lieber , Shovan K Majumder , Joanne Hutchings

DOI: 10.1155/2008/230307

关键词:

摘要: Epithelial cancers, including those of the skin and cervix, are most common type cancers in humans. Many recent studies have attempted to use Raman spectroscopy diagnose these cancers. In this paper, spectral markers related temporal spatial effects cervical examined through four separate but studies. Results from a clinical cervix study show that previous disease has significant effect on signatures which allow for near 100% classification discriminating versus true normal. A microspectroscopy showed can detect changes due adjacent regions dysplasia or HPV cannot be detected histologically, while spectra may detecting malignancy associated tissues surrounding nonmelanoma Finally, results an organotypic raft culture provided support both vitro results. These add growing body evidence optical spectroscopy, case markers, used subtle tissue cancerous sites go otherwise undetected by conventional histology.

参考文章(53)
Thomas B. Fitzpatrick, Dermatology in general medicine McGraw-Hill. ,(1971)
Barbara S. Ducatman, Donald A. Antonioli, Louis Burke, Colposcopy Text and Atlas ,(1990)
Michael T. Fahey, Les Irwig, Petra Macaskill, Meta-analysis of Pap Test Accuracy American Journal of Epidemiology. ,vol. 141, pp. 680- 689 ,(1995) , 10.1093/OXFORDJOURNALS.AJE.A117485
P. Crow, A. Molckovsky, N. Stone, J. Uff, B. Wilson, L.-M. WongKeeSong, Assessment of fiberoptic near-infrared raman spectroscopy for diagnosis of bladder and prostate cancer Urology. ,vol. 65, pp. 1126- 1130 ,(2005) , 10.1016/J.UROLOGY.2004.12.058
Chad A. Lieber, Shovan K. Majumder, Darrel L. Ellis, D. Dean Billheimer, Anita Mahadevan-Jansen, In vivo nonmelanoma skin cancer diagnosis using Raman microspectroscopy. Lasers in Surgery and Medicine. ,vol. 40, pp. 461- 467 ,(2008) , 10.1002/LSM.20653
Amy Robichaux-Viehoever, Elizabeth Kanter, Heidi Shappell, Dean Billheimer, Howard Jones, Anita Mahadevan-Jansen, Characterization of Raman Spectra Measured in Vivo for the Detection of Cervical Dysplasia Applied Spectroscopy. ,vol. 61, pp. 986- 993 ,(2007) , 10.1366/000370207781746053
G Shetty, C Kendall, N Shepherd, N Stone, H Barr, Raman spectroscopy: elucidation of biochemical changes in carcinogenesis of oesophagus. British Journal of Cancer. ,vol. 94, pp. 1460- 1464 ,(2006) , 10.1038/SJ.BJC.6603102
Junghyun Choi, Jaebum Choo, Hoeil Chung, Dae-Gab Gweon, Jeunghee Park, Hyo Jin Kim, Sangyong Park, Chil-Hwan Oh, Direct observation of spectral differences between normal and basal cell carcinoma (BCC) tissues using confocal Raman microscopy Biopolymers. ,vol. 77, pp. 264- 272 ,(2005) , 10.1002/BIP.20236
M. V. P. Chowdary, K. Kalyan Kumar, Jacob Kurien, Stanley Mathew, C. Murali Krishna, Discrimination of normal, benign, and malignant breast tissues by Raman spectroscopy Biopolymers. ,vol. 83, pp. 556- 569 ,(2006) , 10.1002/BIP.20586