The phylogeny of human chromosome specific alpha satellites

摘要: The chromosomal distribution of sequences homologous to 18 coned alpha satellite fragments was established by in situ hybridization. It appeared that all the cloned were members small repeated families located on single chromosome pairs. Among studied specific molecular markers for chromosomes 3, 4, 10,11,17,18 and X found. Comparison hybridization spectra obtained under non-stringent conditions restriction site periodicities different chromosome-specific allowed identification three “suprachromosomal” families, each a characteristic set chromosomes. together cover autosomes chromosome. These data plus those reported previously allow part phylogenetic tree repeats be drawn. Each suprachromosomal family has presumably originated from distinct ancestral sequence consists certain types monomers. Ancestral have evolved into number cycles interchromosomal transfers subsequent amplification events. high homogeneity may result intrachromosomal homogenization units domains.