摘要: Cell cycle progression in eukaryotic cells is governed by a series of cyclins and cyclin dependent kinases. Individual act at different phases the cell binding stimulating activities cdk’s. Because these cdk’s are pivotal to control thereby proliferation, mutational changes alterations expression corresponding genes play critical role transformation tumor (for reviews, see Sherr, 1996; Hunter, 1997). In epithelial most affect requirement respond external growth factors adhere onto extracellular matrix components for involve regulatory circuits controlling transitions G1 S phase cycle.
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