作者: H. Lorberboum-Galski , D. FitzGerald , V. Chaudhary , S. Adhya , I. Pastan
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摘要: Abstract A cDNA clone for human interleukin 2 (IL-2) has been fused to the 5' end of a modified Pseudomonas exotoxin (PE) gene that lacks sequences encoding cell recognition domain. The chimeric protein IL-2-PE40 was produced in Escherichia coli. It extremely toxic IL-2 receptor-positive cells but had no measurable effect on lacking receptor. might be useful cytotoxic agent treatment diseases involving and allograft rejection.