An Evaluation of Nasal Response following Different Treatment Regimes of Oxymetazoline with Reference to Rebound Congestion

摘要: This was a randomized, double-blind vehicle controlled study aimed at investigating the effects on nasal function of 7 days treatment with topical decongestant oxymetazoline (0.05% w/v). Fifty healthy volunteers took part in and these were randomly allocated to three groups (i) daily (b.i.d. 150 microliters per nostril) (ii) intermittent oxymetazoline, being substituted for morning doses 1, 3, 7; (iii) nostril). The airway assessed by measurement resistance (NAR) using posterior rhinomanometry, subjective scaling patency means visual analogue scale (VAS), clinical examination. On 2, 7, NAR VAS measurements obtained before dose up 6 hours after dosing; examinations also performed dosing days. made following withdrawal Days 8 9. Nonparametric analysis results showed that therapeutic tolerance did not develop over 7-day period, examination mucosa failed find significant evidence rhinitis. Evidence rebound congestion found 3 treatment, baseline within significantly greater Day compared 1 (p < 0.05). However, there trend toward increasing group course study, suggesting may have contributed congestion. Following treatments, only had higher 9 Subjective generally followed trends NAR.