Structural and functional magnetic resonance imaging in psychiatric disorders

摘要: Objective: To report on recent advances in both structural and functional brain imaging studies psychiatry to highlight their importance for the field. Method: We reviewed recently published articles dealing with such abstracted them into a selective review of Results: Some more important trends include integration genetic information research studies, use novel quantitative image measurement techniques, new subject populations, pharmacologic probes magnetic resonance (fMRI) incorporation elements virtual reality fMRI task stimuli, methodological innovation hyperscanning. Conclusions: A whole series approaches techniques are resulting rapid neuroimaging psychiatry. Several these show potential clinical translation. (Can J Psychiatry 2007;52:158-166) Information funding support author affiliations appears at end article. Clinical Implications * Quantitative measurements obtained from beginning illuminate our understanding disease mechanisms schizophrenia cross traditional diagnostic boundaries. Future definitions (and many other psychiatric illnesses) will likely come rely measures. Limitations The recent, most informative brain-imaging currently not widely available outside specialized centres. Such measures also generally group, rather than an individual, level. Key Words: imaging, diffusion tensor independent component analysis field disorders has made enormous since first computed tomography patients chronic some 30 years ago. leading "neuroimaging genomics." Other major influences last few involve developed including VBM algorithms fusion images different modalities (for example, sMRI fMRI). Although widespread availability whole-brain voxel-based as expanded number structures that can be easily rapidly assessed, debate over comparability this technique hand-drawn ROIs is fully resolved. Also examination far wider spectrum inclusion unaffected first-degree relatives, well large numbers subjects, often necessitating multisite collaborations. discussed newer strategies neuroimaging, pharmacologie stimuli incorporating reality, methodologic comprehensive reviews describe regions circuits implicated various mental illnesses enumerate affected areas.1-4 Rather resummarizing catalogue involved disorders, it greater intrinsic interest we contemporary themes serving motivate efforts without controversial aspects, so debates concerning application. Let us start overview. discuss disciplines genomics.5 One comment on, but do explore further, move away examining single, isolated toward neural circuits. …