The Opposing Actions of Target of Rapamycin and AMP-Activated Protein Kinase in Cell Growth Control
作者： Sravanth K. Hindupur , Asier González , Michael N. Hall
DOI: 10.1101/CSHPERSPECT.A019141
关键词:
摘要: Cell growth is a highly regulated, plastic process. Its control involves balancing positive regulation of anabolic processes with negative catabolic processes. Although target rapamycin (TOR) major promoter in response to nutrients and factors, AMP-activated protein kinase (AMPK) suppresses energy stress. Both TOR AMPK are conserved throughout eukaryotic evolution. Here, we review the fundamentally important roles these two kinases cell particular emphasis on their mutually antagonistic signaling.
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