The specific activities of mesophilic and thermophilic proteinases.

摘要: Abstract 1. Most enzymes from extreme thermophiles do not possess higher specific activities than similar mesophiles (measured at their respective growth temperatures). 2. However, using protein substrates, the of thermophilic proteinases are considerably those most microbial and eukaryotic proteinases. 3. This property could be attributed to purely kinetic influences on enzyme, some “design” feature proteinase, or effects temperature substrate. 4. Comparisons rates hydrolysis large small substrates by both mesophilic suggest that temperature-induced changes in substrate susceptibility a major factor.