STAT3 and apoptosis regulators: Bak and Bcl-xL in endometrioid adenocarcinomas of different estrogen receptor-𝛂 immunoprofile
作者： Andrzej Wincewicz , Marek Baltaziak , Luiza Kanczuga-Koda , Mariusz Koda , Urszula Sulkowska
DOI: 10.3109/09513590.2010.507286
关键词:
摘要: Estrogen receptor (ER) is a major feature of endometrioid adenocarcinoma. It has significant impact on constitution estrogen-responsiveness this endometrial malignancy, in which STAT3 (signal transducer and activator transcription) becomes hyperactivated. The aim our study was to detect immunohistochemically compare expressions with apoptosis regulators (Bak Bcl-xL) regard different pathological features variably pronounced ER-α immunoprofile 78 adenocarcinomas. abundantly detected nuclei cancer cells 54 cases, thus pointing at its activation as an universal nuclear transcriptional factor. Bcl-xL Bak were expressed cytoplasm malignant 62 20 cancers, respectively. correlated both (p = 0.001, r = 0.365) (p < 0.001, r = 0.436) all adenocarcinomas subgroups these tumours segregated grading, staging patients' age. Remarkabl...
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