MicroRNAs in endometrial cancers from black and white patients.

摘要: Objective Previous studies have identified differences in gene mutations among endometrial cancers from whites and blacks suggesting that tumor biology may explain racial disparities patient outcome. Micro RNAs (miRNAs) emerged as regulators of transcript expression their aberrant has been discovered many diseases, including cancer. We performed quantitative polymerase chain reaction–based analysis a set to identify whether there are miRNA expression. Study Design Tumor cells 50 stage-I endometrioid cancer specimens 41 white 9 black patients were prepared by laser microdissection extracts analyzed using TaqMan (Life Technologies, Carlsbad, CA) low-density arrays. Statistically significant, differentially expressed miRNAs between multidimensional scaling, Wilcoxon testing, variance. Results There no global patients. To minimize potential bias introduced unbalanced sample size, we subset with stage- histology-matched 18 abundant (>2-fold at P Conclusion These data indicate hsa-mir-337-3p is more frequently down-regulated compared blacks. Future focused on determining the phenotypic impact miR-337-3p its differential associated clinical