Distinguishing pca3 messenger rna species in benign and malignant prostate tissues
作者： Camille Chypre , Yves Fradet , Ursula Busse
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摘要: This invention concerns the discovery of two distinct PCA3 mRNA sequences. One these sequences corresponds to a short molecule whereas other RNA is longer as it comprises an additional sequence between exon 3 and 4a. The associated with prostate cancer long non-malignant state prostate. Based on differential expression levels sequences, protocols for diagnosis disease are provided. also relates therapeutic approaches cancer.
lens.org参考文章(220)
James Iwakiri, Kay Grandbois, Nancy Wehner, Howard C.B. Graves, Thomas Stamey, An Analysis of Urinary Prostate Specific Antigen Before and After Radical Prostatectomy: Evidence for Secretion of Prostate Specific Antigen by the Periurethral Glands Journal of Urology. ,vol. 149, pp. 783- 786 ,(1993) , 10.1016/S0022-5347(17)36207-9
Xandra O. Breakefield, Ole Isacson, William S. Rosenberg, Method of gene delivery to post-mitotic cells ,(1992)
W. Scott Grayburn, Thomas L. Sims, Anchored oligo(dT) primers for automated dye terminator DNA sequencing. BioTechniques. ,vol. 25, pp. 340- 346 ,(1998) , 10.2144/98253BM01
Stephen C. Macevicz, Nucleic acid sequence determination by multiple mixed oligonucleotide probes ,(1988)
Michael K. Brawer, Michael P. Chetner, Jeanette Beatie, David M. Buchner, Robert L. Vessella, Paul H. Lange, Screening for Prostatic Carcinoma with Prostate Specific Antigen The Journal of Urology. ,vol. 147, pp. 841- 845 ,(1992) , 10.1016/S0022-5347(17)37401-3
Kamoi K, Babaian Rj, Advances in the application of prostate-specific antigen in the detection of early-stage prostate cancer. Seminars in Oncology. ,vol. 26, pp. 140- 149 ,(1999)
Paul S. Miller, Paul O.P. Ts'o, Chapter 30. Oligonucleotide Inhibitors of Gene Expression in Living Cells: New Opportunities in Drug Design Annual Reports in Medicinal Chemistry. ,vol. 23, pp. 295- 304 ,(1988) , 10.1016/S0065-7743(08)60858-1
Hans Georg Ihlenfeldt, Gertraud Ehrlich-Weinreich, Christoph Seidel, Ursula Henrike Wienhues, Hubert Bayer, Günther Gerhard Jung, HCV peptide antigens and methods for the determination of HCV ,(1992)
R. Lathe, Synthetic oligonucleotide probes deduced from amino acid sequence data. Theoretical and practical considerations. Journal of Molecular Biology. ,vol. 183, pp. 1- 12 ,(1985) , 10.1016/0022-2836(85)90276-1
Ying Z. Grasso, Craig D. Zippe, Manjula K. Gupta, Howard S. Levin, Eric A. Klein, Combined Nested RT-PCR Assay for Prostate-specific Antigen and Prostate-specific Membrane Antigen in Prostate Cancer Patients: Correlation with Pathological Stage Cancer Research. ,vol. 58, pp. 1456- 1459 ,(1998)