Modulation of gene transcription and epigenetics of colon carcinoma cells by bacterial membrane vesicles

摘要: Interactions between bacteria and colon cancer cells influence the transcription of host cell. Yet is it undetermined whether itself or communication responsible for genomic changes in eukaryotic Now, we have investigated epigenetic consequences co-culturing colorectal carcinoma with membrane vesicles from pathogenic Vibrio cholerae non-pathogenic commensal Escherichia coli. Our study reveals that a global impact on gene expression colon-carcinoma cells. The correlate positively both chromatin accessibility promoters at start sites genes induced by types vesicles. Moreover, demonstrated obtained only V. associated epithelial cell differentiation. Altogether, our suggests observed might be due to specific components do not require direct contact bacteria.