The adult Göttingen minipig as a model for chronic heart failure after myocardial infarction: focus on cardiovascular imaging and regenerative therapies.

摘要: Porcine models have become increasingly popular in cardiovascular research. The standard farm pig rapidly increases body weight and size, potentially confounding serial measurements of cardiac function morphology. We developed an adult porcine model that does not show physiologic heart mass during the study period is suitable for long-term study. compared minipigs with commonly used adolescent Yorkshire swine. Myocardial infarction was induced Gottingen swine by occlusion left anterior descending coronary artery followed reperfusion. At 8 wk after infarction, ventricular ejection fraction 34.1 +/- 2.3% 30.7 2.0% end-diastolic pigs assessed magnetic resonance imaging increased 17 5 g, from 42.6 4.3 g at week 1 to 52.8 6.6 8, whereas it remained unchanged minipigs. Cardiac anatomy physiology were evaluated invasively angiography noninvasively Multidetector Computed Tomography Magnetic Resonance Imaging 1.5 T 3 prior myocardial folow-up. This failure reproducible, mimics pathophysiology patients who experienced studies. New therapies devices can be tested preclinically this animal chronic failure.