Streptococcus uberis-specific T cells are present in mammary gland secretions of cows and can be activated to kill S. uberis.
作者： Michel Denis , S. Jane Lacy-Hulbert , Bryce M. Buddle , John H. Williamson , D. Neil Wedlock
DOI: 10.1007/S11259-011-9462-1
关键词:
摘要: The presence, phenotype and function of Streptococcus uberis-specific T cells in the mammary gland secretion (MGS) blood cows exposed to S. uberis were assessed. MGS udder purified incubated with autologous monocytes as antigen-presenting (APC). Most cows, irrespective prior infection status lactation status, shown have both blood. When from a subgroup studied, it was found that produced high levels interferon-gamma (IFN-γ), but low interleukin-10 (IL-10). A percentage responding CD8 + memory (CD45RO) subset. specific for propagated animals during drying off period expanded vitro using interleukin-2 (IL-2) antigens. This led accumulation subset bearing cell markers (CD45A − , CD45RO ), which released IFN-γ. Four five lines derived three had substantial direct killing activity towards vitro. It is concluded there an emergence bactericidal after or environmental exposure uberis. Vaccines aimed at activating expanding this population glands cattle may offer avenue prevention mastitis caused by
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