Effect of coffee consumption on dyslipidemia: A meta-analysis of randomized controlled trials

摘要: Abstract Background and aim Dyslipidemia is a common metabolic disease worldwide also an important predisposing factor for cardiovascular diseases (CVDs). Coffee loved by people all over the world; however, association between coffee consumption blood lipids has yielded inconsistent results. So we carried this meta-analysis to explore effects of on lipids. Methods results Medline, PubMed, Web science, Embase, Cochrane Library databases were systematically searched until April 2020. Combined weighted mean differences (WMD) with their 95% confidence interval (CI) calculated using random-effects models, between-study heterogeneity was assessed Cochran's Q test I2 statistics. Subgroup analysis meta-regression conducted potential heterogeneity. A total 12 RCT studies involving lipid levels included in meta-analysis. The pooled showed that significantly increased cholesterol (TC) (WMD: 0.21 mmol/L, CI: 0.04; 0.39, P = 0.017), triglyceride (TG) 0.12 mmol/L, 0.03; 0.20, P = 0.006) low-density lipoprotein (LDL-C) 0.14 mmol/L, 0.05; 0.24, P = 0.003) while had no significant effect high-density (HDL-C) −0.01 mmol/L, −0.06; 0.04, P = 0.707). Dose–response revealed positive nonlinear associations increase TC, LDL-C, TG levels. Conclusions Evidence from suggested may be associated elevated risk dyslipidemia CVDs. reasonable habit (