The Effects of the Decaffeination of Coffee Samples on Platelet Aggregation in Hyperlipidemic Rats

摘要: The effect of coffee on cardiovascular diseases is still controversial. It known that the process decaffeination may influence chemical constitution and, therefore, biological effects coffee. This study thus evaluated levels total phenols and chlorogenic acids in Coffea arabica L. samples, as well ingesting both integral decaffeinated lipid profile hemostatic hematological parameters normal hyperlipidemic rats. Samples lyophilized (Coffea L., planted Brazil) were used for analysis (total phenols, acid caffeine contents). For bioassays, beverages prepared with non-lyophilized samples (10% w/v) filtered administered to animals by gavage (7.2 mL/kg/day) over 30 days. On 31st day after beginning treatment beverages, hyperlipidemia was induced administering Triton WR-1339 (300 mg/kg body weight). 32, blood taken determine profile, platelet aggregation, prothrombin time, partially activated thromboplastin time hemogram. contents phenolic compounds beverage significantly lower than those beverage. treated presented a mixed hyperlipidemia. Although caused relative increase acids, drinks unable change or studied animals.