A mechanism of cyclin D1 action encoded in the patterns of gene expression in human cancer.
作者： Justin Lamb , Sridhar Ramaswamy , Heide L. Ford , Bernardo Contreras , Robert V. Martinez
DOI: 10.1016/S0092-8674(03)00570-1
关键词:
摘要: Abstract Here we describe how patterns of gene expression in human tumors have been deconvoluted to reveal a mechanism action for the cyclin D1 oncogene. Computational analysis thousands genes across hundreds tumor specimens suggested that transcription factor, C/EBPβ/Nf-Il6, participates consequences overexpression. Functional analyses confirmed involvement C/EBPβ regulation affected by and established this protein as an indispensable effector potentially important facet biology. This work demonstrates databases can be used study function oncogene situ.
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