Granulomas are a source of interleukin-33 expression in pulmonary and extrapulmonary sarcoidosis

摘要: Sarcoidosis is a chronic inflammatory disease characterized by noncaseating epithelioid granulomas. These granulomas consist of highly differentiated mononuclear phagocytes--epithelioid cells and multinucleated giant (MNGCs)--surrounded proinflammatory infiltrate. Interleukin-33 (IL-33) an cytokine that constitutively expressed in barrier tissues such as skin lung up-regulated inflammation. Because sarcoidosis occurs most frequently skin, we studied the expression this immunohistochemistry these from patients with sarcoidosis, foreign body granulomas, other granulomatous diseases, corresponding normal tissues. We identified nuclear IL-33 staining MNGCs biopsies (18/25 patients, 72%) (10/19 53%) sarcoidosis. In contrast, sarcoidal lymph nodes did not show expression. Other diseases showed only occasional weak found strong correlation between systemic disease, presence MNGCs, M2-like macrophage phenotype assessed CD163 staining. Therefore, propose plays critical role pathogenesis progression less commonly weakly detection might serve adjunctive diagnostic marker. seems to be dependent on specific tissue microenvironment represents novel biomarker for involvement.