Advanced magnetic resonance imaging and metabolic studies of low grade gliomas in childhood

摘要: Introduction: Paediatric low grade brain tumours present diagnostic and prognostic challenges, providing a need for better non-invasive imaging characterization. The value of \(^1\)H Magnetic Resonance Spectroscopy (MRS) performed on 5 scanners in the diagnosis prognostication an extensive bi-centre cohort low-grade gliomas is investigated. Methods: Single voxel MRS was routinely children with at Birmingham Children’s Hospital Queen’s Medical Centre. Histopathological features were semi-quantified vitro NMR used to study pilocytic astrocytoma cell lines. Spectroscopic Imaging (MRSI) texture analysis MR images performed. Results: detects differences between subgroups same histology. High myo-inositol glycerophosphocholine phosphocholine are markers good prognosis. Histological correlates metabolites have been identified paediatric lines (‘typical’, metastatic recurrence) discriminated. MRSI answering clinical questions has demonstrated. Texture achieved high accuracy posterior fossa tumours. Conclusion: Advanced techniques significant role tumours, promising results from MRS, reported here.