Safety and efficacy of panitumumab therapy after progression with cetuximab: experience at two institutions.

摘要: Abstract Introduction Cetuximab therapy has been effectively combined with cytotoxic chemotherapy in the first-, second-, and third-line treatment settings. In general, cetuximab is well tolerated, though it associated development of hypersensitivity reactions (HSRs). case severe HSRs, further not possible. contrast cetuximab, HSRs have rarely observed panitumumab therapy. Currently, indicated for patients metastatic colorectal cancer (mCRC) progressive refractory disease, there recent evidence documenting its clinical efficacy first-line second-line However, safety after progression documented. Patients Methods We present a retrospective review our experience treating 15 mCRC who tolerated benefit failure on from November 2006 through September 2008 at Yale Cancer Center New Haven, CT Saint Francis Treatment Grand Island, NE. KRAS status was retrospectively assessed readily available tumor tissue. Results All were treated standard dose 6 mg/kg intravenously every 2 weeks. No patient received premedication Of treated, 4 only doses but stopped because deterioration performance status. 11 evaluable patients, we noted minor radiographic responses (Response Evaluation Criteria Solid Tumors) 3 stable disease (SD) other 8 weeks Five had stopped. The median duration SD months (range, 2-8 months). Among 1 achieved > 50% reduction carcinoembryonic antigen (CEA; 112 to 49 U/L), 25% (59 43 U/L, 84 61 67 42 CEA (98 83 U/L). no occurrence reactions. Grade 3/4 toxicities skin rash 5 asthenia patient. adverse events included grade 1-2 paronychia hypomagnesemia fatigue patients. One wild-type KRAS, this individual experienced response antibody CEA. A second found mutant and, terms response, months. third evaluated unable tolerate more than therefore response. Conclusion Panitumumab may represent an alternative strategy including cetuximab-based regimens. Our relatively small suggests that exert their antitumor activity different mechanisms; however, work required investigate potentially interesting issue.