Systemic Therapy for Colorectal Cancer

作者: Jeffrey A. Meyerhardt , Robert J. Mayer

DOI: 10.1056/NEJMRA040958

关键词:

摘要: Colorectal cancer is one of the most commonly diagnosed malignant diseases, with an estimated 1,023,000 new cases and 529,000 deaths worldwide each year. This review considers recently developed cytotoxic chemotherapies biologic agents that are effective against colorectal assesses their use as treatments for metastatic disease components adjuvant therapy.

参考文章(103)
Jimmy J Hwang, John L Marshall, Steven G Eisenberg, Improving the toxicity of irinotecan/5-FU/leucovorin: a 21-day schedule. Oncology. ,vol. 17, pp. 37- 43 ,(2003)
Jordan D. Berlin, Targeting vascular endothelial growth factor in colorectal cancer. Oncology. ,vol. 16, pp. 13- 15 ,(2002)
David Edler, Bengt Glimelius, Wilhelm Graf, Ake Berglund, Daniel Molin, Hans Nordlinder, Thymidylate synthase and p53 expression in primary tumor do not predict chemotherapy outcome in metastatic colorectal carcinoma. Anticancer Research. ,vol. 22, pp. 3653- 3659 ,(2002)
N. Wolmark, S. Wieand, B. Lembersky, L. Colangelo, R. Smith, R. Pazdur, A phase III trial comparing oral UFT to FULV in stage II and III carcinoma of the colon: Results of NSABP Protocol C-06 Journal of Clinical Oncology. ,vol. 22, pp. 3508- 3508 ,(2004) , 10.1200/JCO.2004.22.90140.3508
Matthias Lorenz, Hans-Helge Müller, Harald Schramm, Heinz-Jochen Gassel, Hans-Günther Rau, Karsten Ridwelski, Johann Hauss, Rudolf Stieger, Karl-Walter Jauch, Wolf O. Bechstein, Albrecht Encke, Randomized Trial of Surgery Versus Surgery Followed by Adjuvant Hepatic Arterial Infusion With 5-Fluorouracil and Folinic Acid for Liver Metastases of Colorectal Cancer Annals of Surgery. ,vol. 228, pp. 756- 762 ,(1998) , 10.1097/00000658-199812000-00006
Robbert J. van Alphen, Alex Sparreboom, Kees Nooter, Ron H. J. Mathijssen, Walter J. Loos, Gerrit Stoter, Jaap Verweij, Clinical pharmacokinetics and metabolism of irinotecan (CPT-11) Clinical Cancer Research. ,vol. 7, pp. 2182- 2194 ,(2001)
A Sulkes, S E Benner, R M Canetta, Uracil-ftorafur: an oral fluoropyrimidine active in colorectal cancer. Journal of Clinical Oncology. ,vol. 16, pp. 3461- 3475 ,(1998) , 10.1200/JCO.1998.16.10.3461
C G Moertel, T R Fleming, J S Macdonald, D G Haller, J A Laurie, C M Tangen, J S Ungerleider, W A Emerson, D C Tormey, J H Glick, Intergroup study of fluorouracil plus levamisole as adjuvant therapy for stage II/Dukes' B2 colon cancer. Journal of Clinical Oncology. ,vol. 13, pp. 2936- 2943 ,(1995) , 10.1200/JCO.1995.13.12.2936
Norman Wolmark, Howard Rockette, Eleftherios Mamounas, Judy Jones, Sam Wieand, DL Wickerham, Harry D Bear, James N Atkins, Nikolay V Dimitrov, Andrew G Glass, Edwin R Fisher, Bernard Fisher, None, Clinical Trial to Assess the Relative Efficacy of Fluorouracil and Leucovorin, Fluorouracil and Levamisole, and Fluorouracil, Leucovorin, and Levamisole in Patients With Dukes' B and C Carcinoma of the Colon: Results From National Surgical Adjuvant Breast and Bowel Project C-04 Journal of Clinical Oncology. ,vol. 17, pp. 3553- 3559 ,(1999) , 10.1200/JCO.1999.17.11.3553